General Cell Based Assays
Sigma Aldrich Fine Chemicals Biosciences Af HDL and LDL/VLDL Assay
Cholesterol concentrations in High-Density Lipoprotein (HDL) and Low-Density (LDL)/Very-Low-Density (VLDL) Lipoproteins are strong predictors for coronary heart disease. functional HDL offers protection by removing cholesterol from cells and atheroma. Higher concentrations of LDL and lower concentrations of functional HDL are strongly associated with cardiovascular disease due to higher risk of atherosclerosis. The balances between high- and low-density lipoproteins are solely genetically determined but can be changed by medications food choices and other factors. Simple direct and automation-ready procedures for measuring HDL and LDL/VLDL concentrations are very desirable.
Meso Scale Discovery U-PLEX Human TRAIL ASY
The U-PLEX Human TRAIL Assay K151XTK from Meso Scale Discovery is a multiplex immunoassay kit for the quantitative measurement of TRAIL in human serum plasma and cell culture supernatants The assay utilizes MSD s electrochemiluminescent detection technology and is provided in a 96-well plate format The kit includes a plate coated with capture antibodies detection antibodies calibrators and diluents The assay has a typical sensitivity of 0 3 pg/mL and an upper limit of quantification of 2500 pg/mL for TRAIL The total assay time is approximately 3 5 hours This product allows for the accurate quantitation of TRAIL across a wide dynamic range
Waters Corp The Quest for Ultra Performance in Liquid Chromatography - Origins of UPLC Technology
The Quest for Ultra Performance in Liquid Chromatography - Origins of UPLC Technology
Abcam ROS/Superoxide Detection Assay Kit (Cell-based)
ROS/Superoxide Detection Assay Kit (Cell-based)
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical 33-BCRP InhIbItr 10mg
A BCRP inhibitor; sensitizes mitoxantrone-resistant H460/MX20 cells to mitoxantrone-induced cell death alone and in combination with UV radiation; sensitizes KB-C2 cells overexpressing P-gp to colchicine-induced cell death; increases intracellular accumulation of mitoxantrone in H460/MX20 cells at 5 µM
Eurofins Discoverx PathHunter eXpress Flt3 ActivityAssay, 10-Plate Kit. (93-0901E3CP16L)
The PathHunter FLT3 Activity eXpress kit provides an easy-to-use cell based assay to study small molecule drug candidates targeting RTKs. This kit assesses RTK activity via detection of resulting FLT3 phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged FLT3 to the extracellular ligand binding domain of EGFR alongside an EA-tagged SH2 domain protein. Upon ligand induced receptor activation, cross-phosphorylation of the receptor leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter GHSR Bioassay Kit, 10-Plate. (93-0242Y3-00142)
The PathHunter GHSR Bioassay kit provides a robust, highly sensitive, and easy-to-use functional cell based assay to measure drug potency and detect neutralizing antibodies. The bioassay kit contains all the materials needed for a complete assay including cryopreserved cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The ready-to-use cryopreserved cells have been manufactured to ensure long-term assay reproducibility, and faster implementation from characterization to lot release. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress GLP1R CHO-K1 β-Arrestin-1 GPCR Assay, 2-Plate Kit. (93-0914E2CP2M)
The PathHunter GLP1R (ARR1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. exendin-4) based activation of GLP1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GLP1R and EA-tagged β-Arrestin-1. Activation of GLP1R stimulates the recruitment of β-Arrestin-1 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Med Vet International Zoetis QuestPlus, Equine Oral Gel, 14g Syringe
QuestPlus (moxidectin/praziquantel) Equine Oral Gel when administered at the recommended dose level of 0.4 mg moxidectin/kg and 2.5 mg praziquantel/kg (2.2 lb) body weight treats and controls large strongyles, small strongyles, encysted cyathostomes, ascarids, pinworms, hairworms, large-mouth stomach worms, horse stomach bots, and tapeworms. Also suppresses strongyle egg production for 84 days. For horses and ponies 6 months of age or older. Safe for pregnant mares. See package insert for complete product details.Products are not always manufacturer specific. Actual product appearance may differ from website image.
Meso Scale Discovery R-PLEX AB40 4G8 ASY
The Meso Scale Discovery R-PLEX Human Abeta40 4G8 Assay Kit is a multiplex immunoassay that measures Abeta40 levels in human samples such as serum plasma CSF and cell culture supernatants It uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision The kit includes a plate coated with a 4G8 antibody to capture Abeta40 along with detection antibodies calibrators controls buffers and other reagents needed to run the assay It allows rapid and accurate quantification of Abeta40 levels which may be useful as a biomarker in Alzheimer s disease research and drug development
Eurofins Discoverx InCELL Hunter eXpress CLK1 Kinase Binding Assay, 2pl Kit. (96-0059E1CP0M)
The InCELL Hunter eXpress CLK1 Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of CLK1 via detection of CLK1 levels. This product uses EFC technology. The cell line included overexpresses CLK1 target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Aat Bioquest iFluor™ 647 azide
AAT Bioquest's iFluor™ dyes are optimized for labeling proteins, in particular, antibodies. These dyes are bright, photostable and have minimal quenching on proteins.
Eurofins Discoverx PathHunter eXpress PTAFR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0236E2CP0M)
The PathHunter PTAFR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PAF) based activation of PTAFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTAFR and EA-tagged β-Arrestin-2. Activation of PTAFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress PTAFR CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0236E2CP0L)
The PathHunter PTAFR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PAF) based activation of PTAFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTAFR and EA-tagged β-Arrestin-2. Activation of PTAFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress ADCYAP1R1 (PAC1) CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0249E2CP0L)
The PathHunter ADCYAP1R1 (PAC1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PACAP) based activation of ADCYAP1R1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADCYAP1R1 and EA-tagged β-Arrestin-2. Activation of ADCYAP1R1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.